Endogenous opioids are naturally occurring substances in the body that have pain-relieving and mood-enhancing effects similar to opiates, such as morphine and heroin. The body produces these substances and including endorphins, enkephalins, and dynorphins. Endogenous opioids play an important role in regulating pain and producing feelings of pleasure, reward, and well-being. However, excessive release of these substances can result in feelings of euphoria and can contribute to the development of opioid tolerance and dependence. Substance abuse can also interfere with the normal functioning of the endogenous opioid system, leading to decreased production of these natural painkillers and increased pain sensitivity. Understanding the role of endogenous opioids in the body can help develop more effective and targeted treatments for addiction and pain management.