The mu-opioid receptor (MOR) is a protein found in the body that is involved in regulating pain and emotions. It is part of the body’s endogenous opioid system and is one of the main targets of opioids, such as morphine, fentanyl, and oxycodone. When opioids bind to the mu-opioid receptor, they activate the receptor and produce their characteristic effects, such as pain relief, sedation, and feelings of euphoria.
The mu opioid receptor is located in various brain and spinal cord regions. It is involved in several functions, including the regulation of pain signaling, the release of hormones and neurotransmitters, and the regulation of breathing.
The activation of the mu-opioid receptor by opioids can result in physical dependence. It can lead to the development of tolerance, in which larger doses of the drug are needed to produce the same effect. The mu opioid receptor is a target of research for developing new treatments for pain, addiction, and other conditions.