Dictionary

Reversed tolerance, also known as tolerance reversal or sensitization, refers to a phenomenon in which a person who has developed a tolerance to a substance, such as alcohol or drugs, begins to experience a heightened sensitivity to the effects of that substance after a period of abstinence. This means that after a period of not using the substance, a person may experience greater effects from smaller amounts of the substance than before.

Reversed tolerance can make a person more vulnerable to overdose, especially if they resume using the substance at their previous level of consumption. It is important for individuals in recovery from addiction to be aware of reversed tolerance and to avoid using substances in amounts that may put them at risk for harm. It is also important for healthcare providers to closely monitor individuals in recovery, especially if they have a history of substance abuse.